Publications

Research articles
patents
Book chapters/highlights/forwards

RESEARCH ARTICLES

  1. Johansen-Leete, J.; Zhong, Y.; Cui, B.; Sebold, B. C.; Kambanis, L.; Clarke-Shepperson, C. E.; Lehmann, C.; Toby Mak, K. H.; Tang, A. H.; Burchfield, J.; Becker, W.; Perdomo, J.; McDonald, D. M.; Corcilius, L.; Passioura, T.; Passam, F. H.; Ford, D. J.; Payne, R. J. Ribosomal Translation and Display Selection of Cyclic Glycopeptides through Genetic Reprogramming. J. Am. Chem. Soc. 2026, 148 (10), 10321-10328. DOI: 10.1021/jacs.5c22682.
  2. Barter, I. K.; Bedding, M. J.; Leodolter, J.; Maxwell, J. W. C.; Hawkins, P. M. E.; Stevens, M. T.; McNeil, M. B.; Jowsey, W. J.; Wang, T.; Quan, D.; Junker, S.; Florido, M.; Hesselson, D.; Cook, G. M.; Clausen, T.; Britton, W. J.; Larance, M.; Payne, R. J. ClpC1-targeting peptide natural products differentially dysregulate the proteome of Mycobacterium tuberculosis. Nat. Commun. 2026, 17 (1), 1725. DOI: 10.1038/s41467-026-68423-2.
  3. Kunwar, S.; Devkota, S. R.; Ang, C.; Aryal, P.; Gai, W.; Pokhrel, R.; So, S. S.; Jiao, W.; Payne, R. J.; Robert, R.; Stone, M. J.; Bhusal, R. P. Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity. Structure 2026. DOI: 10.1016/j.str.2026.02.001.
  4. Tang, A. H.; Soler, N. M.; Karlic, K. I.; Corcilius, L.; Clarke-Shepperson, C. E.; Lehmann, C.; Debowski, A. W.; Dale, A. L.; Zavan, L.; Cielesh, M.; Adewale, A. P.; Moulton, K. D.; Li, L.; Guan, C.; McCrory, C.; Kaparakis-Liaskos, M.; Howden, B. P.; Sherry, N. L.; Wei, R.; Li, X.; Hall, R. M.; Kenyon, J. J.; Wakim, L. M.; Short, F. L.; Dube, D. H.; Cordwell, S. J.; Larance, M.; Stubbs, K. A.; Carter, G. P.; Scott, N. E.; Goddard-Borger, E. D.; Payne, R. J. Uncovering bacterial pseudaminylation with pan-specific antibody tools. Nat. Chem. Biol. 2026. DOI: 10.1038/s41589-025-02114-9.
  5. Jing, X.; Suh, J.; Maxwell, J.; Patel, K.; Norman, A.; Reid, X. J.; Deshpande, C.; Low, J. K. K.; Payne, R. J.; Passioura, T.; Mackay, J. P. The effect of peptide size on target affinity in mRNA display-derived macrocyclic peptides. Chem. Commun. (Camb.) 2026. DOI: 10.1039/d5cc06167a
  6. Buchanan, J. A.; Lavidis, O.; Shields, N.; Harrison, K.; Nguyen, H. T.; Payne, R. J.; Passioura, T.; Steain, M.; Sunde, M. De novo cyclic peptides allow visualisation of the monomeric and functional amyloid conformations of the kinase RIPK3. Biochem. J. 2026. DOI: 10.1042/BCJ20250283
  7. Lambrechts, L. S.; Reid, X. J.; Kambanis, L.; Luong, C.; Kobakhidze, E.; Daners, A.; Zhong, Y.; Patel, K.; Franck, C. K.; Sani, H. M.; Taylor, C.; Payne, R. J.; Mackay, J. P. The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation. Nucleic Acids Res. 2025, 53 (22). DOI: 10.1093/nar/gkaf1406
  8. Kambanis, L.; Dilly, J. J.; Maxwell, J. W. C.; Stockdale, S.; Fry, S. E.; Harrison, K.; Byrne, S. N.; Ashhurst, A. S.; Kulkarni, S. S.; Payne, R. J. Semi-Synthesis of Immunogenic Mycobacterial Lipoproteins via Aryl Selenoester-Mediated Expressed Protein Ligation. Angew. Chem. Int. Ed. Engl. 2025, e19647. DOI: 10.1002/anie.202519647
  9. Hawkins, P. M. E.; Bedding, M. J.; Hoi, D. M.; Barter, I. K.; Cheung, C.-Y.; Oehlers, S. H.; Cook, G. M.; Clausen, T.; Britton, W. J.; Payne, R. J. ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials. ACS Infect. Dis. 2025, 11 (11), 3298-3309. DOI: 10.1021/acsinfecdis.5c00689.
  10. Masson, S. W. C.; Simpson, R. C.; Cutler, H. B.; Carlos, P. W.; Marian, O. C.; Yau, B.; Potter, M.; Madsen, S.; Cooke, K. C.; Craw, N. R.; Fuller, O. K.; Harney, D. J.; Larance, M.; Cooney, G. J.; Morahan, G.; Shanahan, E. R.; Kebede, M. A.; Hodgkins, C.; Payne, R. J.; Stockli, J.; James, D. E. Genetic variance in the murine defensin locus modulates glucose homeostasis. EMBO J. 2025. DOI: 10.1038/s44318-025-00555-5.
  11. Maxwell, J. W. C.; Ripoll-Rozada, J.; Mackay, A. S.; Alwis, I.; Ford, D. J.; Trought, C. B. J.; Santos, J. A.; Smythe, R. E.; Liu, J. S. T.; Zuccolotto, Z.; Schoenwaelder, S. M.; Jackson, S. P.; Pereira, P. J. B.; Payne, R. J. Engineering Ultrapotent Trivalent Anticoagulants Through Hybridisation of Salivary Peptides from Multiple Haematophagous Organisms. Chem. Sci. 2025, in press. DOI: 10.1039/d5sc04734j. *Part of the Chemical Science 15th Anniversary Issue.
  12. Stewart, E. L.; Stockdale, S.; Johansen, M. D.; Smith, L.; Alca, S.; Maxwell, J. W. C.; Nguyen, D. H.; Miemczyk, S.; Zhao, G.; Turville, S.; Triccas, J. A.; Steain, M.; Byrne, S. N.; Hansbro, P. M.; Payne, R. J.; Britton, W. J.; Ashhurst, A. S. Upper respiratory tract immunization with Pam2Cys-adjuvanted spike protein vaccine achieves sterilizing protection against SARS-CoV-2. Front. Immunol. 2025, 16. DOI: 10.3389/fimmu.2025.1654126.
  13. Kambanis, L.; Chisholm, T. S.; Egelund, P. H.; Kulkarni, S. S.; Payne, R. J. One-pot iterative native chemical ligation-desulfurization chemistry leveraging a coumarin-based photolabile protecting group for cysteine. Aust. J. Chem. 2025, in press. *Invited submission to celebrate the 70th birthday of Prof David Craik FRS FAA.
  14. Jiramongkol, Y.; Patel, K.; Johansen-Leete, J.; Maxwell, J. W. C.; Chang, Y.; Du, J. J.; Passioura, T.; Cook, K. M.; Payne, R. J.; White, M. D. An mRNA-display derived cyclic peptide scaffold reveals the substrate binding interactions of an N-terminal cysteine oxidase. Nat. Commun. 2025, 16 (1). DOI: 10.1038/s41467-025-59960-3.
  15. Wang, X. S.; Jiou, J.; Cerra, A.; Cobbold, S. A.; Jochem, M.; Mak, K. H. T.; Corcilius, L.; Silke, J.; Payne, R. J.; Goddard-Borger, E. D.; Komander, D.; Lechtenberg, B. C. The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro. Life Sci. Alliance 2025, 8 (6). DOI: 10.26508/lsa.202503243.
  16. Dockerill, M.; Ford, D. J.; Angerani, S.; Alwis, I.; Dowman, L. J.; Ripoll-Rozada, J.; Smythe, R. E.; Liu, J. S. T.; Pereira, P. J. B.; Jackson, S. P.; Payne, R.J.; Winssinger, N. Development of supramolecular anticoagulants with on-demand reversibility. Nat. Biotechnol. 2025, 43, 186–193. DOI: 10.1038/s41587-024-02209-z.
  17. Dickerhof, N.; Ashby, L. V.; Ford, D.; Dilly, J. J.; Anderson, R. F.; Payne, R. J.; Kettle, A. J. Dioxygenation of tryptophan residues by superoxide and myeloperoxidase. J. Biol. Chem. 2025, 108402. DOI: 10.1016/j.jbc.2025.108402.
  18. Hao, H.; Yuan, Y.; Ito, A.; Eberand, B. M.; Tjondro, H.; Cielesh, M.; Norris, N.; Moreno, C. L.; Maxwell, J. W. C.; Neely, G. G.; Payne, R. J.; Kebede, M. A.; Urbauer, R. J. B.; Passam, F. H.; Larance, M.; Haltiwanger, R. S. FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Nat. Chem. Biol. 2025. DOI: 10.1038/s41589-024-01815-x.
  19. Stevens, M. T.; Hawkins, P. M. E.; Wang, T.; Payne, R. J.; Britton, W. J. Analogue of the natural product ecumicin causes sustained growth inhibition of Mycobacterium tuberculosis under multiple growth conditions. Tuberculosis 2025, 151, 102594. DOI: https://doi.org/10.1016/j.tube.2024.102594.
  20. Zhang, B. B.; Harrison, K.; Zhong, Y.; Maxwell, J. W. C.; Ford, D. J.; Calvey, L. P.; So, S. S.; Peterson, F. C.; Volkman, B. F.; Stone, M. J.; Bhusal, R. P.; Kulkarni, S. S.; Payne, R. J. Discovery of Selective Cyclic D-Sulfopeptide Ligands of the Chemokine CCL22 via Mirror-Image mRNA Display with Genetic Reprogramming. J. Am. Chem. Soc. 2024, 146 (50), 34253-34259. DOI: 10.1021/jacs.4c12057.
  21. Bedding, M. J.; Forster, B. C.; Giltrap, A. M.; Stevens, M. T.; Corcilius, L.; Britton, W. J.; Payne, R. J. Modular Total Synthesis and Antimycobacterial Activity of Rufomycins. Org. Lett. 2024, 26, 50, 10993–10998. DOI: 10.1021/acs.orglett.4c04163.
  22. Luz, J. d.; Dobah, F.; Rossi-Ashton, J.; Payne, R. J.; Unsworth, W.; Petersen, W. Dehydrogenative Photoredox Catalyzed Synthesis of Indolyl Δ2‐Isoxazolines via a Formal C(sp3)–H Functionalization. Eur. J. Org. Chem. 2024. DOI: 10.1002/ejoc.202401369.
  23. Maxwell, J. W. C.; Stockdale, S.; Stewart, E. L.; Ashley, C. L.; Smith, L. J.; Steain, M.; Triccas, J. A.; Byrne, S. N.; Britton, W. J.; Ashhurst, A. S.; Payne, R. J. Intranasal Self-Adjuvanted Lipopeptide Vaccines Elicit High Antibody Titers and Strong Cellular Responses against SARS-CoV-2. ACS Infect. Dis. 2024, 10 (9), 3419-3429. DOI: 10.1021/acsinfecdis.4c00544.
  24. Patel, K.; Jiramongkol, Y.; Norman, A.; Maxwell, J. W. C.; Mohanty, B.; Payne, R. J.; Cook, K. M.; White, M. D. The enzymatic oxygen sensor cysteamine dioxygenase binds its protein substrates through their N-termini. J. Biol. Chem. 2024, 107653. DOI: 10.1016/j.jbc.2024.107653.
  25. Kambanis, L.; Ayoub, A.; Bedding, M. J.; Egelund, P. H. G.; Maxwell, J. W. C.; Franck, C.; Lambrechts, L.; Hawkins, P. M. E.; Chisholm, T. S.; Mackay, J. P.; Sierecki, E.; Gambin, Y.; Kulkarni, S. S.; Payne, R.J. Expressed Protein Ligation in Flow. J. Am. Chem. Soc. 2024, 146 (31), 22027-22035. DOI: 10.1021/jacs.4c07462.
  26. Dilly, J. J.; Morgan, A. L.; Bedding, M. J.; Low, J. K. K.; Mackay, J. P.; Conibear, A. C.; Bhusal, R. P.; Stone, M. J.; Franck, C.; Payne, R. J. Tyrosine Sulfation Modulates the Binding Affinity of Chemokine-Targeting Nanobodies. ACS Chem. Biol. 2024, 19 (7), 1426-1432. DOI: 10.1021/acschembio.4c00230.
  27. Harrison, K.; Carlos, P.; Ullrich, S.; Aggarwal, A.; Johansen-Leete, J.; Mini Sasi, V.; Barter, I.; Maxwell, J.; Bedding, M.; Larance, M.; Turville, S.; Jackson, C,; Norman, A,; Nitsche, C,; Payne, R. J. Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS-CoV-2 Main Protease with Antiviral Activity. Chem. Eur. J. 2024, e202401606. DOI: https://doi.org/10.1002/chem.202401606.
  28. Devkota, S. R.; Aryal, P.; Wilce, M. C. J.; Payne, R. J.; Stone, M. J.; Bhusal, R. P. Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001. Protein Sci. 2024, 33 (6), e4999. DOI: https://doi.org/10.1002/pro.4999.
  29. Guan, I. A.; Liu, J. S. T.; Sawyer, R. C.; Li, X.; Jiao, W.; Jiramongkol, Y.; White, M. D.; Hagimola, L.; Passam, F. H.; Tran, D. P.; Liu, X.;Schoenwaelder, S. M.; Jackson, S. P.; Payne, R. J.; Liu, X. Integrating Phenotypic and Chemoproteomic Approaches to Identify Covalent Targets of Dietary Electrophiles in Platelets. ACS Central Science 2024, 10 (2), 344–357. DOI: 10.1021/acscentsci.3c00822.
  30. Bedding, M. J.; Franck, C.; Johansen-Leete, J.; Aggarwal, A.; Maxwell, J. W. C.; Patel, K.; Hawkins, P. M. E.; Low, J. K. K.; Siddiquee, R.; Sani, H. M.; Ford, D. J.; Turville, S.; Mackay, J. P.; Passioura, T.; Christie, M.; Payne, R. J. Discovery of High Affinity Cyclic Peptide Ligands for Human ACE2 with SARS-CoV-2 Entry Inhibitory Activity. ACS Chem. Biol. 2024, 19 (1), 141-152.
  31. Chernykh, A.; Abrahams, J. L.; Grant, O. C.; Kambanis, L.; Sumer-Bayraktar, Z.; Ugonotti, J.; Kawahara, R.; Corcilius, L.; Payne, R. J.; Woods, R. J.; Thaysen-Andersen, M. Position-specific N- and O-glycosylation of the reactive centre loop impacts neutrophil elastase-mediated proteolysis of corticosteroid-binding globulin. J. Biol. Chem. 2024, 300 (1), 105519.
  32. Low, J. K. K.; Patel, K.; Jones, N.; Solomon, P.; Norman, A.; Maxwell, J. W. C.; Pachl, P.; Matthews, J. M.; Payne, R. J.; Passioura, T.; Suga, H.; Walport, L. J.; Mackay, J. P. mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome. J. Biol. Chem. 2023, 299 (12), 105482.
  33. Mackay, A. S.; Maxwell, J. W. C.; Bedding, M. J.; Kulkarni, S. S.; Byrne, S. A.; Kambanis, L.; Popescu, M. V.; Paton, R. S.; Malins, L. R.; Ashhurst, A. S.; Corcilius, L.; Payne, R. J. Electrochemical Modification of Polypeptides at Selenocysteine. Angew. Chem. Int. Ed. 2023, 62, e202313037. DOI: 10.1002/anie.202313037.
  34. Maxwell, J. W. C.; Hawkins, P. M. E.; Watson, E. E.; Payne, R. J. Exploiting Chemical Protein Synthesis to Study the Role of Tyrosine Sulfation on Anticoagulants from Hematophagous Organisms. Acc. Chem. Res. 2023, 56 (19), 2688–2699. DOI: 10.1021/acs.accounts.3c00388.
  35. Rathje, O. H.; Perryman, L.; Payne, R. J.; Hamprecht, D. W. PROTACs Targeting MLKL Protect Cells from Necroptosis. J. Med. Chem. 2023, 66 (16), 11216–11236. DOI: 10.1021/acs.jmedchem.3c00665.
  36. Devkota, S. R.; Aryal, P.; Pokhrel, R.; Jiao, W.; Perry, A.; Panjikar, S.; Payne, R. J.; Wilce, M. C. J.; Bhusal, R. P.; Stone, M. J. Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat. Commun. 2023, 14 (1), 4204. DOI: 10.1038/s41467-023-39879-3.
  37. Thijssen, V.; Hurdiss, D. L.; Debski-Antoniak, O. J.; Spence, M. A.; Franck, C.; Norman, A.; Aggarwal, A.; Mokiem, N. J.; van Dongen, D. A. A.; Vermeir, S. W.; Liu, M.; Li, W.; Chatziandreou, M.; Donselaar, T.; Du, W.; Drulyte, I.; Bosch, B. J.; Snijder, J.; Turville, S. G.; Payne, R. J.; Jackson, C. J.; van Kuppeveld, F. J. M.; Jongkees, S. A. K. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proc. Natl. Acad. Sci. U. S. A. 2023, 120 (26), e2303292120. DOI: 10.1073/pnas.2303292120.
  38. Tran, H. N. T.; Budusan, E.; Saez, N. J.; Norman, A.; Tucker, I. J.; King, G. F.; Payne, R. J.; Rash, L. D.; Vetter, I.; Schroeder, C. I. Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a. Org. Lett. 2023, 25 (24), 4439-4444. DOI: 10.1021/acs.orglett.3c01346.
  39. Franck, C.; Patel, K.; Walport, L. J.; Christie, M.; Norman, A.; Passioura, T.; Suga, H.; Payne, R. J.; Mackay, J. P. Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins. Structure 2023, 31 (8), 912-923.E4. DOI: 10.1016/j.str.2023.05.009
  40. Tran, P.; Tran, H. N. T.; McMahon, K. L.; Deuis, J. R.; Ragnarsson, L.; Norman, A.; Sharpe, S. J.; Payne, R. J.; Vetter, I.; Schroeder, C. I. Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific. Bioconj. Chem. 2023, 34 (6), 1072–1083. DOI: 10.1021/acs.bioconjchem.3c00135.
  41. Harrison, K.; Mackay, A. S.; Kambanis, L.; Maxwell, J. W. C.; Payne, R. J. Synthesis and applications of mirror-image proteins. Nat. Rev. Chem. 2023, 7, 383–404. DOI: 10.1038/s41570-023-00493-y.
  42. Hoi, D. M.; Junker, S.; Junk, L.; Fischel, K.; Podlesainski, D.; Schwechel, K.; Kasani, F.; van Geelen, L.; Leodolter, J.; Hawkins, P. M. E.; Morreale, F. E.; Kleine, S.; Guha, S.; Rumpel, K.; Schmiedel, V. M.; Weinstabl, H.; Meinhart, A.; Kalscheuer, R.; Payne, R. J. Kaiser, M.; Hartl, M.; Boehmelt, G.; Kazmaier, U.; Clausen, T. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival Cell 2023, 186(10), 2176-2192.e22.
  43. Tang, A. H.; Payne, R. J. Second Generation Synthesis of the Anti-Infective Natural Product Gallinamide A Tetrahedron 2023, 133445. Invited submission in honor of Professor Chi-Huey Wong’s 2022 Tetrahedron Prize for Creativity in Organic Chemistry
  44. Bartolec, T. K.; Vazquez-Campos, X.; Norman, A.; Luong, C.; Johnson, M.; Payne, R. J.; Wilkins, M. R.; Mackay, J. P.; Low, J. K. K. Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein-protein interactions in the human cell. Proc. Natl. Acad. Sci. U. S. A. 2023, 120 (17), e2219418120. DOI: 10.1073/pnas.2219418120.
  45. Adams, R.; Joyce, C.; Kuravskiy, M.; Harrison, K.; Ahdash, Z.; Balmforth, M.; Chia, K.; Marceddu, C.; Coates, M.; Snowden, J.; Goursaud, M.; Menochet, K.; van den Elsen, J.; Payne, R. J.; Lawson, A. D.; Scott-Tucker, A.; Macpherson, A. Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides. Front. Immunol. 2023, 14. DOI: 10.3389/fimmu.2023.1170357.
  46. Ekanayake, K. B.;  Mahawaththa, M. C.;  Qianzhu, H.;  Abdelkader, E. H.;  George, J.;  Ullrich, S.;  Murphy, R. B.;  Fry, S. E.;  Johansen-Leete, J.;  Payne, R. J.;  Nitsche, C.;  Huber, T.; Otting, G. Probing Ligand Binding Sites on Large Proteins by Nuclear Magnetic Resonance Spectroscopy of Genetically Encoded Non-Canonical Amino Acids. J. Med. Chem. 2023, 66 (7), 5289–5304.
  47. Vigder, N.; Suarna, C.; Corcilius, L.; Nadel, J.; Chen, W.; Payne, R.J.; Tumanov, S.; Stocker, R. An improved method for the detection of myeloperoxidase chlorinating activity in biological systems using the redox probe hydroethidine. Free Radic. Biol. Med. 2023, 195, 23-35.
  48. Ashhurst, A. S.; Johansen, M. D.; Maxwell, J. W. C.; Stockdale, S.; Ashley, C. L.; Aggarwal, A.; Siddiquee, R.; Miemczyk, S.; Nguyen, D. H.; Mackay, J. P.; Counoupas, C.; Byrne, S. N.; Turville, S.; Steain, M.; Triccas, J. A.; Hansbro, P. M.; Payne, R. J.; Britton, W. J. Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice. Nat. Commun. 2022, 13 (1), 6972. DOI: 10.1038/s41467-022-34297-3.
  49. Dowman, L. J.; Kulkarni, S. S.; Alegre-Requena, J. V.; Giltrap, A. M.; Norman, A. R.; Sharma, A.; Gallegos, L. C.; Mackay, A. S.; Welegedara, A. P.; Watson, E. E.; van Raad, D.; Niederacher, G.; Huhmann, S.; Proschogo, N.; Patel, K.; Larance, M.; Becker, C. F. W.; Mackay, J. P.; Lakhwani, G.; Huber, T.; Paton, R. S.; Payne, R. J. Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Nat. Commun. 2022, 13 (1), 6885. DOI: 10.1038/s41467-022-34530-z highlighted in Nature Chemistry, Shining a Light on Diselenide Bonds”, 2023, 15, 163-164.
  50. Sasi, V. M.; Ullrich, S.; Ton, J.; Fry, S. E.; Johansen-Leete, J.; Payne, R. J.; Nitsche, C.; Jackson, C. J. Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening. Biochemistry 2022, 61, 2495-2505 DOI: 10.1021/acs.biochem.2c00489.
  51. Aryal, P.; Devkota, S. R.; Jeevarajah, D.; Law, R.; Payne, R. J.; Bhusal, R. P.; Stone, M. J. Swapping N-terminal regions among tick evasins reveals cooperative interactions influencing chemokine binding and selectivity. J. Biol. Chem. 2022, 298 (10), 102382. DOI: 10.1016/j.jbc.2022.102382
  52. Hanna, C.;  Maxwell, J. W. C.;  Ismanto, H. S.;  Ashhurst, A.;  Artner, L.;  Rudrawar, S.;  Britton, W.;  Yamasaki, S.; Payne, R. J., Synthetic Vaccines Targeting Mincle Through Conjugation of Trehalose Dibehenate. Chem. Commun. 2022, 58, 6890-6893. DOI: 10.1039/D2CC02100E
  53. Johansen-Leete, J.; Payne, R. J., Selenium is the chalcogen of choice for selective reporting of thioredoxin reductase activity. Chem 2022, 8 (5), 1175-1177.
  54. Hawkins, P. M. E.;  Hoi, D. M.;  Cheung, C.-Y.;  Wang, T.;  Quan, D.;  Sasi, V. M.;  Liu, D. Y.;  Linington, R. G.;  Jackson, C. J.;  Oehlers, S. H.;  Cook, G. M.;  Britton, W. J.;  Clausen, T.; Payne, R. J. Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A. J. Med. Chem. 2022, 65 (6), 4893–4908.
  55. Johansen-Leete, J.; Ullrich, S.;  Fry, S. E.;  Frkic, R.; Bedding, M. J.; Aggarwal, A.;  Ashhurst, A. S.; Ekanayake, K. B.; Mahawaththa, M. C.; Sasi, V. M.; Luedtke, S.; Ford, D. J.; O’Donoghue, A. J.; Passioura, T.; Larance, M.; Otting, G.; Turville, S.; Jackson, C. J.; Nitsche, C.; Payne, R. J. Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2. Chem. Sci. 2022, 13, 3826-3836.
  56. Bhusal, R. P.; Aryal, P.; Devkota, S. R.; Pokhrel, R.; Gunzburg, M. J.; Foster, S. R.; Lim, H. D.; Payne, R. J.; Wilce, M. C. J.; Stone, M. J. Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc. Natl. Acad. Sci. U. S. A. 2022, 119(9), e2122105119.
  57. Kulkarni, S.S.; Watson, E.E.; Maxwell, J.W.C.; Niederacher, G.; Johansen-Leete, J.; Huhmann, S.; Mukherjee, S.; Norman, A.R.; Kriegesmann, J.; Becker, C.F.W. and Payne, R.J. Expressed Protein Selenoester Ligation. Angew. Chem. Int. Ed. 2022, 61(20), e202200163
  58. Barbosa Da Silva, E.;  Sharma, V.;  Hernandez-Alvarez, L.;  Tang, A. H.;  Stoye, A.;  O’Donoghue, A. J.;  Gerwick, W. H.;  Payne, R. J.;  McKerrow, J. H.; Podust, L. M., Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against Trypanosoma cruzi. J. Med. Chem. 2022, 65(5), 4255–4269.
  59. Ripoll-Rozada, J.;  Maxwell, J. W. C.;  Payne, R. J.; Barbosa Pereira, P. J., Tyrosine-O-sulfation is a widespread affinity enhancer among thrombin interactors. Biochem. Soc. Trans. 2022, 50(1), 387-401.
  60. Mackay, A. S.; Payne, R. J.; Malins, L. R. Electrochemistry for the Chemoselective Modification of Peptides and Proteins. J. Am. Chem. Soc. 2022, 144(1), 23–41.
  61. Liczner, C.;  Hanna, C.;  Payne, R. J.; Wilds, C. J., Generation of Oligonucleotide Conjugates via One-pot Diselenide-Selenoester Ligation Deselenization / Alkylation. Chem. Sci. 2022, 13, 410-420.
  62. Hanna, C.;  Kriegesmann, J.;  Dowman, L.;  Becker, C.; Payne, R. J. Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angew. Chem. Int. Ed. 2021, 61(15), e202111266.
  63. Hossain, K. R.; Clayton, D.; Goodchild, S. C.; Rodger, A.; Payne, R. J.; Cornelius, F.; Clarke, R. J. Order-disorder transitions of cytoplasmic N-termini in the mechanisms of P-type ATPases, Faraday Discuss., 2021, 232, 172–187. 
  64. Tran, W.;  Kusay, A. S.;  Hawkins, P. M. E.;  Cheung, C.Y.;  Nagalingam, G.;  Pujari, V.;  Ford, D. J.;  Stoye, A.;  Ochoa, J. L.;  Audette, R. E.;  Hortle, E.;  Oehlers, S. H.;  Charman, S. A.;  Linington, R. G.;  Rubin, E. J.;  Dowson, C. G.;  Roper, D. I.;  Crick, D. C.;  Balle, T.;  Cook, G. M.;  Britton, W. J.; Payne, R. J. Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors. J. Med. Chem. 2021. 64 (23), 17326–17345.
  65. Ashhurst, A. S.;  Tang, A. H.;  Fajtová, P.;  Yoon, M. C.;  Aggarwal, A.;  Bedding, M. J.;  Stoye, A.;  Beretta, L.;  Pwee, D.;  Drelich, A.;  Skinner, D.;  Li, L.;  Meek, T. D.;  McKerrow, J. H.;  Hook, V.;  Tseng, C.-T.;  Larance, M.;  Turville, S.;  Gerwick, W. H.;  O’Donoghue, A. J.; Payne, R. J. Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L. J. Med. Chem. 2022, 65(4), 2956–2970.
  66. Duggan, N. M.;  Saez, N. J.;  Clayton, D.;  Budusan, E.;  Watson, E. E.;  Tucker, I. J.;  Rash, L. D.;  King, G. F.; Payne, R. J. Total Synthesis of the Spider-Venom Peptide Hi1a. Org. Lett. 2021, 23 (21), 8375-8379.
  67. Robinson, S. D.;  Kambanis, L.;  Clayton, D.;  Hinneburg, H.;  Corcilius, L.;  Mueller, A.;  Walker, A. A.;  Keramidas, A.;  Kulkarni, S. S.; Jones, A.; Vetter, I.; Thaysen-Andersen, M.; Payne, R.J..; King, G.F.; Undheim, E.A.B. A pain-causing and paralytic ant venom glycopeptide. iScience 2021, 24(10), 103175.
  68. Byrne, S.;  Bedding, M.;  Corcilius, L.;  Ford, D.;  Zhong, Y.;  Franck, C.;  Larance, M.;  Mackay, J.; Payne, R. J. Late-stage modification of peptides and proteins at cysteine with diaryliodonium salts. Chem. Sci. 2021, 12, 14159-14166.
  69. Dowman, L. J.; Agten, S. M.; Ripoll-Rozada, J.; Calisto, B. M.; Pereira, P. J. B.; Payne, R. J. Synthesis and Evaluation of Peptidic Thrombin Inhibitors Bearing Acid-Stable Sulfotyrosine Analogues. Chem. Commun. 2021, 57, 10923-10926.
  70. Kambanis, L.; Chisholm, T. S.; Kulkarni, S. S.; Payne, R. J. Rapid one-pot iterative diselenide-selenoester ligation using a novel coumarin-based photolabile protecting group. Chem. Sci. 2021, 12, 10014-10021.
  71. Hawkins, P. M. E.; Liu, D. Y.; Linington, R. G.; Payne, R. J. Solid-phase synthesis of coralmycin A/epi-coralmycin A and desmethoxycoralmycin.Org. Biomol. Chem. 2021, 19, 6291-6300. *special issue on antibiotic and antiviral compounds.
  72. Queiroz, R. F; Suarna, C.; Corcilius, L.; Sergeant, G. E.; Shengule, S.; Payne, R. J.; Ayer, A.; Stocker, R. Preparation, validation and use of a vasoactive tryptophan-derived hydro peroxide and relevant control compounds. Nat. Protoc. 2021, 16, 3382-3418.
  73. Norman, A.; Franck, C.; Christie, M.; Hawkins, P. M. E.; Patel, K.; Ashhurst, A. S.; Aggarwal, A.; Low, J. K. K.; Siddiquee, R.; Ashley, C. L.; Steain, M.; Triccas, J. A.; Turville, S.; Mackay, J. P.; Passioura, T.; Payne, R. J. Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display. ACS Cent. Sci. 2021, 7 (6), 1001-1008.
  74. Ford, D. J.; Duggan, N. M.; Fry, S. E.; Ripoll-Rozada, J.; Agten, S. A.; Liu, W.; Corcilius, L.; Hackeng, T. M.; van Oerle, R.; Spronk, H. M. H.; Ashhurst, A. S.; Sasi, V. S.; Kaczmarski, J. A.; Jackson, C. J.; Pereira, P. J. B.; Passioura, T.; Suga, H.; Payne, R. J. Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming. J. Med. Chem. 2021, 64 (11), 7853-7876.
  75. Wang, S.; Foster, S. R.; Sanchez, J.; Corcilius, L.; Larance, M.; Canals, M.; Stone, M. J.; Payne, R. J. Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14. ACS Chem. Biol. 2021, 16 (6), 973-981.
  76. Premdjee, B.; Andersen, A. S.; Larance, M.; Conde-Frieboes, K. W.; Payne, R. J. Chemical Synthesis of Phosphorylated Insulin-like Growth Factor Binding Protein 2. J. Am. Chem. Soc. 2021, 143 (14), 5336-5342.
  77. Patel, K.; Solomon, P. D.; Walshe, J. L.; Ford, D. J.; Wilkinson-White, L.; Payne, R. J.; Low, J. K. K.; Mackay, J. P. BET-Family Bromodomains Can Recognize Diacetylated Sequences from Transcription Factors Using a Conserved Mechanism. Biochemistry 2021, 60 (9), 648-662.
  78. Hanna, C. C.; Ashhurst, A. S; Quan, D.; Maxwell, J. W. C.; Britton, W. J.; Payne, R. J. Synthetic protein conjugate vaccines provide protection against Mycobacterium tuberculosis in mice. Proc. Natl. Acad. Sci. U.S.A. 2021, 118 (4), e2013730118.
  79. Agten, S. M.; Watson, E. E.; Ripoll-Rozada, J.; Dowman, L. J.; Wu, M. C. L.; Alwis, I.; Jackson, S. P.; Pereira, P. J. B.; Payne, R. J. Potent trivalent inhibitors of thrombin through hybridization of salivary sulfopeptides from hematophagous arthropods. Angew. Chem. Int. Ed. 2021, 60 (10), 5348-5356. *featured as a cover article and selected as a hot article
  80. Calisto, B. M.; Ripoll-Rozada, J.; Dowman, L. J.; Franck, C.; Agten, S. M.; Parker, B. L.; Veloso, R. C.; Vale, N.; Gomes, P.; de Sanctis, D.; Payne, R. J.; Pereira, P. J. B. Sulfotyrosine-mediated recognition of human thrombin by a tsetse fly anticoagulant mimics physiological substrates. Cell Chem. Biol. 2021, 28 (1), 26-33. *featured as a cover article
  81. Patel, K.; Walport, L. J.; Walshe, J. L.; Soloman, P. D.; Low, J. K. K.; Tran, D. H.; Mouradian, K. S.; Silva, A. P. G.; Wilkinson-White, L.; Norman, A.; Franck, C.; Matthews, J. M.; Guss, J. M.; Payne, R. J.; Passioura, T.; Suga, H.; Mackay, J. P. Cyclic peptides can engage a single binding pocket through highly divergent modes. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (43), 26728-26738.
  82. Clayton, D; Kulkarni, S. S.; Sayers, J.; Dowman, L. J.; Ripoll-Rozada, J.; Pereira, J. B. P.; Payne, R. J. Chemical synthesis of a haemathrin sulfoprotein library reveals enhanced thrombin inhibition following tyrosine sulfation. RSC Chem. Biol. 2020, 1, 379-384.
  83. Wang, X.; Ashhurst, A. S.; Dowman, L. J.; Watson, E. E.; Li, H. Y.; Fairbanks, A. J.; Larance, M.; Kwan, A.; Payne, R. J. Total Synthesis of Glycosylated Interferon-γ. Org. Lett. 2020, 22 (17), 6863-6867.
  84. Maxwell, J. W. C.; Payne, R. J. Revealing the functional roles of tyrosine sulfation using synthetic sulfopeptides and sulfoproteins. Curr. Opin. Chem. Biol. 2020, 58, 72-85.
  85. Fernandes, K. E.; Payne, R. J.; Carter, D. A. Lactoferrin-derived peptide lactofungin is potently synergistic with amphotericin B. Antimicrob. Agents Chemother. 2020, 64 (10) e00842-20.
  86. Wali, J. A.; Koay, Y. C.; Chami, J.; Wood, C.; Corcilius, L.; Payne, R. J.; Rodionov, R. N.; Birkenfeld, A. L.; Samocha-Bonet, D.; Simpson, S. J.; O’Sullivan, J. F. Nutritional and metabolic regulation of the metabolite Dimethylguanidino Valeric Acid – an early marker of cardio metabolic disease. Am. J. Physiol. Endocrinol. Metab. 2020, 319 (3), e509-e518.
  87. Hawkins, P.; Tran, W.; Nagalingam, G.; Cheung, C. Y.; Giltrap, A. M.; Cook, G.; Britton, W. J.; Payne, R. J. Total Synthesis and Antimycobacterial Activity of Ohmyungsamycin A, Deoxyecumicin, and Ecumicin. Chem. Eur. J. 2020. 26 (66), 15200-15205.
  88. Franck, C.; Foster, S. R.; Johansen-Leete, J.; Chowdhury, S.; Cielesh, M.; Bhusal, R. P.; Mackay, J. P.; Larance, M.; Stone, M. J.; Payne, R. J. Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (23), 12657-12664.
  89. Johansen-Leete, J.; Passioura, T.; Foster, S.; Bhusal, R.; Ford, D.; Liu, M.; Jongkees, S.; Suga, H.; Stone, M. J.; Payne, R. J. Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display. J. Am. Chem. Soc. 2020, 142 (20), 9141-9146.
  90. Chung, J. H.; Tang, A. H.; Geraghty, K.; Corcilius, L.; Kaiser, M.; Payne, R. J. Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues. Org. Lett. 2020, 22 (8), 3089-3093.
  91. Zhong, Y.; Paudel, B. P.; Ryan, D. P.; Low, J. K. K.; Franck, C.; Patel, K.; Bedward, M. J.; Torrado, M.; Payne, R. J.; van Oijen, A. M.; Mackay, J. P. CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation. Nat. Commun. 2020, 11, 1519.
  92. Chisholm, T. S.; Kulkarni, S. S.; Hossain, K. R.; Cornelius, F.; Clarke, R. J.; Payne, R. J. Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation. J. Am. Chem. Soc. 2020, 142 (2), 1090-1100.
  93. Wang, X.; Corcilius, L.; Premdjee, B.; Payne, R. J. Synthesis and Utility of ß-Selenophenylalanine and ß-Selenoleucine in Diselenide-Selenoester Ligation (DSL). J. Org. Chem. 2020, 85 (3), 1567-1578. Invited article for a special issue on ‘Modern Peptide and Protein Chemistry’
  94. Karas, J. A.; Chen, F.; Schneider-Futschik, E. K.; Kang, Z.; Hussein, M.; Swarbrick, J.; Hoyer, D.; Giltrap, A. M.; Payne, R. J.; Li, J.; Velkov, T. Synthesis and Structure-Activity Relationships of Teixobactin. Ann. N. Y. Acad. Sci. 2020, 1459 (1), 86-105.
  95. Chiorean, S.; Antiwi, I.; Carney, D. W.; Kotsogianni, I.; Giltrap, A. M.; Alexander, F. M.; Cochrane, S. A.; Payne, R. J.; Martin, N. I.; Henninot, A.; Vederas, J. C. Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II. ChemBioChem. 2020, 21 (6), 789-792.
  96. Watson, E. E.; Ripoll-Rozada, J.; Lee, A. C.; Wu, M. C, L.; Pasch, T.; Premdjee, B.; Franck, C.; Sayers, J.; Pinto, M. F.; Martins, P. M.; Jackson, S. P.; Pereira, P. J. B.;Payne, R. J. Rapid Assembly of a Library of Anticoagulant Sulfoproteins. Proc. Natl. Acad. Sci. U. S. A. 2019, 116 (28), 13873-13878.
  97. Pinto, M. F.; Ripoll-Rozada, J.; Ramos, H.; Watson, E. E.; Franck, C.; Payne, R. J.; Saraiva, L.; Pereira, P. J. B.; Pastore, A.; Rocha, F.; Martins, P. M. A Simple Linearization Method Unveils Hidden Enzymatic Assay Interfaces. Biophys. Chem. 2019, 252, 106193.
  98. Ashhurst, A; McDonald, D.; Hanna, C.; Stanojevic, V.; Britton, W. J.; Payne R. J. Mucosal Vaccination with a Self-adjuvanted Lipopetide is Immunogenic and Protective against Mycobacterium Tuberculosis. J. Med. Chem. 2019, 62 (17), 8080-8089.
  99. Kulkarni, S.; Watson, E. E.; Premdjee, B.; Conde-Frieboes, K. W.; Payne, R. J. Diselenide-Selenoester Ligation for Chemical Protein Synthesis. Nat. Protoc. 2019, 14, 2229-2257.
  100. Stoye, A.; Juillard, A.; Tang, A. H.; Legac, J.; Gut, J.; White, K.; Charman, S. A.; Rosenthal, P. J.; Grau, G. E. R.; Hunt, N. H.; Payne, R. J. Falcipain Inhibitors Based on the Natural product Gallinamide A are Potent in vitro and in vivo Antimalarials. J. Med. Chem. 2019, 62 (11), 5562-5578.
  101. Wei, R; Liu, H, Tang, A. H.; Payne, R. J.; Li, X. A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation. Org. Lett. 2019, 21 (10), 3584-3588.
  102. Stanley, C. P.; Maghzal, G. J.; Shengule, S.; Giltrap, A. M.; Ayer, A.; Talib, J.; Chadha, P.; Prysyazhna, O.; Dunn, L. L.; Prado, F. M.; Stasch, J-P.; Yamamoto, Y.; Di Mascio, P.; Eaton, P.; Payne, R. J.; Stocker, R. Singlet Molecular Oxygen Regulates Vascular Tone and Blood Pressure in Inflammation. Nature, 2019, 566 (7745), 548-552.
  103. Sanchez, J.; E Huma, Z.; Lane, J. R.; Liu, X.; Bridgford, J. L.; Payne, R. J.; Canals, M.; Stone, M. J. Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1. J. Biol. Chem. 2019, 294 (10), 3464-3475.
  104. Hastwell, A. H.; Corcilius, L.; Williams, J. T.; Gresshoff, P. M.; Payne, R. J.; Ferguson, B. J. Triarabinosylation is required for nodulation-suppressive CLE peptides to systemically inhibit nodulation in Pisum sativum. Plant Cell Environ. 2019, 42 (1), 188-197.
  105. Conibear, A.; Watson, E. E.; Payne, R. J. Becker, C. F. W. Native Chemical Ligation in Protein Synthesis and Semi-Synthesis. Chem. Soc. Rev. 2018, 47 (24), 9046-9068. (invited review for special issue on “Protein Engineering”).
  106. McDonald, D.; Hanna, C.; Ashhurst, A.; Corcilius, L.; Byrne, S.; Payne, R. J. Synthesis of a Self-adjuvanting MUC1 Vaccine via Diselenide-Selenoester Ligation-Deselenization. ACS Chem. Biol. 2018, 13 (12), 3279-3285.
  107. Sayers, J.; Karpati, P. M. T.; Mitchell, N. J.; Goldys, A. M.; Kwong, S. M.; Firth, N.; Chan, B.; Payne R. J. Construction of Challenging Proline-Proline Junctions via Diselenide-Selenoester Ligation Chemistry. J. Am. Chem. Soc. 2018, 140(41), 13327-13334.
  108. Payne, R. J.; Winssinger, N. Editoral overview: Synthetic biomolecules. Current Opinion in Chemical Biology. 2018, 46, A3-A4.
  109. Robinson, S. D.; Mueller, A.; Clayton, D.; Starobova, H.; Hamilton, B. R.; Payne, R. J.; Vetter, I.; King, G. F.; Undheim, E. A. B. A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family. Science Adv. 2018, 4(9), eaau4640.
  110. Corcilius, L. C.; Liu, D. Y.; Ochoa, J. L.; Linington, R. G.; Payne, R. J. Synthesis and evaluation of analogues of the glycinocin family of calcium-dependent antibiotics. Org. Biomol. Chem. 2018, 16 (29), 5310-5320.
  111. Chisholm, T. S.; Clayton, D.; Dowman, L. J.; Sayers, J.; Payne, R. J. Native Chemical Ligation-Photodesulfurization in Flow. J. Am. Chem. Soc. 2018, 140 (29), 9020-9024. (journal cover image)
  112. Giltrap, A. M.; Haeckl, F. P. J.; Kurita, K. L.; Linington, R. G.; Payne, R. J. Synthetic Studies Towards the Skyllamycins: Total Synthesis and Generation of Simplified Analogues. J. Org. Chem. 2018, 83 (13), 7250-7270.
  113. Craik, D. J.; Payne, R. J. Emerging peptide Science in Australia (editorial). J. Pept. Sci. 2018, DOI: 10.1002/pep2.24080. (see cover image).
  114. Watson, E. E.; Liu, X.; Thompson, R. E.; Ripoll-Rozada, J.; Wu, M.; Alwis, I.; Gori, A.; Loh, C-T.; Parker, B. L.; Otting, G.; Jackson, S.; Pereira, P. J. B.; Payne, R. J. Mosquito-Derived Anophelin Sulfoproteins are Potent Anti-thrombotics. ACS Cent. Sci. 2018, 4 (4), 468-476.
  115. Kulkarni, S.; Sayers, J.; Premdjee, B.; Payne, R. J. Rapid and Efficient Protein Synthesis Through Expansion of the Native Chemical Ligation Concept. Nat. Rev. Chem. 2018, 2, 0122.
  116. Je, B. I.; Xu, F.; Wu, Q.; Liu, L.; Meeley, R.; Gallagher, J. P.; Corcilius, L.; Payne, R. J.; Bartlett, M. E.; Jackson, D. The CLAVATA receptor FASCIATED EAR2 responds to distinct CLE peptides by signalling through two downstream effectors. ELife, 2018, 7, e35673.
  117. Nguyen K.; Garcia, A.; Sani, M. A.; Diaz, D.; Dubey, V.; Clayton, D.; Dal Poggetto, G.; Cornelius, F.; Payne, R. J.; Separovic, F.; Khandelia, H.; Clarke, R. J. Interaction of N-terminal peptide analogues of the Na+,K+-ATPase with membranes. Biochim. Biophys. Acta, 2018, 1860 (6), 1282-1291.
  118. Payne, R. J. Preface: Bioactive Molecules Australasia. Tetrahedron, 2018, 74 (12), 1165-1166.
  119. Imin, N.; Patel, N.; Corcilius, L.; Payne, R. J.; Djordjevic, M. CLE peptide tri-arabinosylation and peptide domain sequence composition are essential for SUNN-dependent autoregulation of nodulation in Medicago truncatula. New Phytologist, 2018, 218 (1), 73-80.
  120. Hawkins, P. M. E.; Giltrap, A. M.; Nagalingam, G.; Britton, W. J.; Payne, R. J. Total synthesis of ecumicin. Org. Lett. 2018, 20 (4), 1019-1022.
  121. Sayers, J.; Payne, R. J.; Winssinger, N. Peptide Nucleic Acid-Templated Selenocytine-Selenoester Ligation Enables Rapid miRNA Detection. Chem. Sci. 2018, 9, 896-903.
  122. Corcilius, L.; Elias, N. T.; Ochoa, J. L.; Linington, R. G.; Payne, R. J. Total synthesis of glycinocins A-C. J. Org. Chem. 2017, 82 (23), 12778-12785.
  123. Patel, N.; Mohd-Radzman, N.; Corcilius, L.; Crossett, B.; Connolly, A.; Cordwell, S.; Ivanovici, A.; Taylor, K.; Williams, J.; Binos, S.; Mariani, M.; Payne, R. J.; Djordjevic, M. Diverse peptide hormones affecting root growth identified in the Medicago truncatula secreted peptidome. Mol. Cell. Prot., 2017, 17 (1), 160-174.
  124. Pang, S. S.; Wijeyewickrema, L. C.; Hor, L.; Tan, S.; Lameignere, E.; Conway, E. M.; Mohlin, F.; Blom, A.; Liu, X.; Payne, R. J.; Whisstock, J. C.; Pike, R. N. The Structural Basis of Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech. J. Immunol. 2017, 199 (11), 3883-3891.
  125. Parker, B. L.; Burchfield, J.; Clayton, D.; Payne, R. J.; Kiens, B.; Wojtaszewski, J.; Richter, E.; James, D. Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Mol. Cell. Prot., 2017, 16 (12), 2055-2068.
  126. Giltrap, A.; Haeckl, J.; Kurita, K.; Linington, R. G.; Payne, R. J. Total Synthesis of Skyllamycins A-C. Chem. Eur. J. 2017, 23 (60), 15046-15049.
  127. Croft, K.D.; Zhang, D.; Jiang, R.; Ayer, A.; Shengule, S.; Payne, R.J.; Ward, N.C. and Stocker, R. Structural requirements of flavonoids to induce heme oxygenase-1. Free Radical Biology and Medicine, 2017, 113, 165-175.
  128. Corcilius, L.; Hastwell, A. H.; Zhang, M.; Williams, J.; Mackay, J. P.; Gresshoff, P. M.; Ferguson, B. J.; Payne, R. J. Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean. Cell Chem. Biol. 2017, 24 (11), 1347-1355.
  129. Araman, C.; Thompson, R. E.; Wang, S.; Hackl, S.; Payne, R. J.; Becker, C. F. W. Semisynthetic Prion Protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils. Chem. Sci. 2017, 8(9), 6626-6632.
  130. Hayward, J.; Sanchez, J.; Perry, A.; Huang, C.; Valle, M. R.; Canals, M.; Payne, R. J.; Stone, M. J. Ticks from diverse genera encode chemokine-inhibitory evasin proteins. J. Biol. Chem. 2017, 292 (38), 15670-15680.
  131. Phillips A. J.; Taleski, D.; Koplinski, C. A.; Getschman, A. E.; Moussouras, N. A.; Richard, A. M.; Peterson, F. C.; Dwinell, M. B.; Volkman, B. F.; Payne, R. J.; Veldkamp, C. T. CCR7 Sulfotyrosine Enhances CCL21 Binding. Int. J .Mol. Sci. 2017, 18 (9), 1857.
  132. Mitchell, N. J.; Sayers, J.; Kulkarni, S. S.; Clayton, D.; Goldys, A. M.; Ripoll-Rozada, J.; Pereira, P. J. B.; Chan, B.; Radom, L.; Payne, R. J. Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry. Chem. 2017, 2(5), 703–715.
  133. Wang, X.; Sanchez, J.; Stone, M. Payne, R. J. Sulfation of Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES. Angew. Chem. Int. Ed. 2017, 56 (29), 8490-8494.
  134. Hanna, C. C.; Kulkarni, S. S.; Watson, E. E.; Premdjee, B.; Payne, R. J. Solid-Phase Synthesis of Peptide Selenoesters via a Side-Chain Anchoring Strategy. Chem. Commun. 2017, 53, 5424-5427.
  135. McAuley, J. L.; Corcilius, L.; Tan, H. X.; Payne, R. J.; McGuckin, M. A.; Brown, L. E. The cell surface mucin MUC1 limits the severity of influenza A virus infection. Mucosal Immunol. 2017, 10, 1581-1593.
  136. Quan, D.; Nagalingam, G.; Payne, R. J. Triccas, J. A. New Tuberculosis Drug Leads from Naturally Occuring Compounds. Int. J. Infect. Dis. 2017, 56, 212-220.
  137. Thompson, R. E.; Liu, X.; Ripoll-Rozada, J.; Alonso-Garcia, N.; Parker, B. L.; Pereira, P. J. B.; Payne, R. J. Tyrosine sulfation modulates activity of tick-derived thrombin inhibitors. Nat. Chem. 2017, 9, 909-917.
  138. Wang, S.; Corcilius, L.; Sharp, P. P.; Payne, R. J. Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments. Bioorg. Med. Chem. 2017, 25(11), 2895-2900.
  139. Tran, A. T.; Watson, E. E.; Pujari, V.; Conroy, T.; Dowman, L. J.; Giltrap, A. M.; Pang, A.; Wong, W.; Linington, R. G.; Mahapatra, S.; Saunders, J.; Charman, S. A.; West, N. P.; Bugg, T. D. H.; Tod, J.; Dowson, C. G.; Roper, D. I.; Crick, D. C.; Britton, W. J.; Payne, R. J. Sansanmycin Natural Product Analogues as Potent and Selective Anti-Mycobacterials that Inhibit Lipid I Biosynthesis. Nat. Commun. 2017, 8, 14414.
  140. Wang, S.; Corcilius, L.; Sharp, P. P.; Rajkovic, A.; Ibba, M.; Parker, B. L.; Payne, R. J. Synthesis of rhamnosylated arginine glycopeptides and determination of the glycosidic linkage in bacterial elongation factor P. Chem. Sci. 2017, 8, 2296-2302.
  141. Mitchell, N. J.; Kulkarni, S.; Wang, S. Malins, L. R. Payne, R. J. One-Pot Ligation-Oxidative Deselenization at Selenocysteine and Selenocystine. Chem. Eur. J. 2017, 23, 946-952. (selected as a “hot paper”).
  142. Stoye, A.; Nagalingam, G.; Britton, W. J.; Payne, R. J. Synthesis of Norfijimycin A with activity against Mycobacterium tuberculosis. Aust. J. Chem. 2017, 70, 229-232. (invited submission for special issue on Australian Peptide Science).
  143. O’Connor, G. D.; Chan, B.; Sanelli, J. A.; Cergol, K.; Dryza, V.; Payne, R. J.; Bieske, E.; Radom, L.; Schmidt, T. W. Hydrogen-adduction to Open-Shell Graphene Fragments: Spectroscopy, Thermochemistry and Astrochemistry. Chem. Sci., 2017, 8, 1186-1194.
  144. Isahak, N.; Gody, G.; Malins, L. R.; Mitchell, N. J. Payne, R. J.; Perrier, S. Single Addition of an Allyl Amine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation. Chem. Commun. 2016, 52(88), 12952-12955.
  145. Giltrap, A. M.; Dowman, L. J.; Nagalingam, G.; Ochoa, J. L,; Linington, R. G.; Britton, W. J.; Payne RJ. Total Synthesis of Teixobactin. Org. Lett. 2016, 18(11), 2788-2791.
  146. Isahak, N.; Sanchez, J.; Perrier, S.; Stone, M. J.; Payne, R. J. Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding. Org. Biomol. Chem. 2016, 14(24), 5652-5658.
  147. Rogers, S.; Fey, D.; McCloy, R. A.; Parker, B. L.; Mitchell, N. J.; Payne, R. J.; Daly, R. J.; James, D. E.; Caldon, C. E.; Watkins, D. N.; Croucher, D. R.; Burgess, A. PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. J. Cell Sci. 2016, 129(7), 1340-1354.
  148. Williams, J. T.; Corcilius, L.; Kiefel, M. J.; Payne, R. J. Total Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid. J. Org. Chem. 2016, 81(6), 2607-2611.
  149. Kiermaier, E.; Moussion, C.; Veldkamp, C. T.; Gerardy-Schahn, R.; de Vries, I.; Williams, L. G.; Chaffee, G. R.; Phillips, A. J.; Freiberger, F.; Imre, R.; Taleski, D.; Payne, R. J.; Braun, A.; Förster, R.; Mechtler, K.; Mühlenhoff, M.; Volkman, B. F.; Sixt, M. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science, 2016, 351(6269), 186-190.
  150. Mitchell, N. J.; Malins, L. R.; Liu, X.; Thompson, R. E.; Chan, B.; Radom, L.; Payne, R. J. Rapid Additive-Free Selenocystine–Selenoester Peptide Ligation. J. Am. Chem. Soc. 2015, 137(44), 14011-14014.
  151. Bashiri, G.; Johnston, J. M.; Evans, G. L.; Bulloch, E. M.; Goldstone, D. C.; Jirgis, E. N.; Kleinboelting, S.; Castell, A.; Ramsay, R. J.; Manos-Turvey, A.; Payne, R. J.; Lott, J. S. Baker, E. N. Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallogr. D Biol. Crystallogr., 2015, 71(11), 2297-2308.
  152. Sayers, J.; Thompson, R. E.; Perry, K. J.; Malins, L. R.; Payne, R. J. Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation-Desulfurization Chemistry. Org. Lett. 2015, 17(19), 4902-4905.
  153. McDonald, D. M.; Byrne, S. N.; Payne, R. J. Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines. Front. Chem., 2015. [DOI: 10.3389/fchem.2015.00060]
  154. Malins, L. R.; Mitchell, N. J.; McGowan, S.; Payne, R. J. Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine. Angew. Chem. Int. Ed. 2015, 54(43), 12716-12721.
  155. Watson, G.; Gunzburg, M.; Ambaye, N.; Lucas, W.; Traore, D.; Kulkarni, K.; Cergol, K.; Payne, R. J.; Panjikar, S.; Pero, S.; Perlmutter, P.; Wilce, M.; Wilce, J. Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target. J. Med. Chem. 2015, 58(19), 7707-7718.
  156. Santhakumar, G.; Payne, R. J. Studies Toward the Total Synthesis and Stereochemical Assignment of Microspinosamide. Aust. J. Chem. 2015, 68(12), 1885-1889. (special issue for SynthCon3).
  157. Stone, M. J.; Payne, R. J. Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications To Characterize the Effects of Tyrosine Sulfation on Biochemical Function. Acc. Chem. Res., 2015, 48(8), 2251–2261.
  158. Reeks, T.; Jones, A.; Brust, A.; Sridharan, S.; Corcilius, L.; Wilkinson, B. L.; Thaysen-Andersen, M.; Payne, R. J.; Kini, R. M.; Daly, N. L.; Alewood, P. F. A bifunctional O-glycosylated natriuretic peptide, TcNP-a, from the venom of Tropidechis carinatus has a defined alpha helix. Angew. Chem. Int. Ed. 2015, 54(16), 4828-4831.
  159. Malins, L. R.; Giltrap, A. M.; Dowman, L. J.; Payne, R. J. Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation–Desulfurization Chemistry. Org. Lett. 2015, 17(9), 2070-2073.
  160. Malins, L. R.; Payne, R. J. Synthetic Amino Acids for Applications in Peptide Ligation-Desulfurization Chemistry. Aust. J. Chem. 2015, 68(4), 521-537. (Invited submission for lead review article for the Sir John Cornforth Commemorative issue).
  161. Ludeman, J. P.; Nazari-Robati, M.; Wilkinson, B. L.; Huang, C.; Payne, R. J.; Stone, M. J. Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Org. Biomol. Chem. 2015, 13(7), 2162-2169.
  162. Manos-Turvey, A. Watson,E. E.; Sykes,M. L.; Jones,A. J. Baell, J. B. Kaiser,M.; Avery, V. M.; Payne, R. J. Synthesis and Evaluation of Phenoxymethylbenzamide Analogues as Anti-Trypanosomal Agent. Med. Chem. Commun. 2015, 6, 403-406. (Invited submission for special issue New Talent: Asia-Pacific).
  163. Conroy T.; Guo, J. T.; Elias, N.; Cergol, K. M.; Gut, J.; Legac, J.; Khatoon, L.; Liu, Y.; McGowan, S.; Rosenthal, P. J.; Hunt, N. H.; Payne, R. J. Synthesis of Gallinamide A Analogues as Potent Falcipain Inhibitors and Antimalarials. J. Med. Chem. 2014, 57(24), 10557-10563.
  164. Millard, C. J.; Ludeman, J. P.; Canals, M.; Bridgford, J. L.; Hinds, M. G.; Clayton, D. J.; Christopoulos, A.; Payne, R. J.; Stone, M. J. Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-Terminal Region of CCR3 Bound to CCL11/Eotaxin-1. Structure, 2014, 22, 1571–1581. (highlighted in a preview article in Structure “Chemokine-Receptor Interactions: Solving the Puzzle, Piece by Piece”).
  165. Malins, L. R.; Payne, R. J. Recent Extensions to Native Chemical Ligation for the Chemical Synthesis of Peptides and Proteins. Curr. Opin. Chem. Biol. 2014, 22, 70-78.
  166. Santhakumar, G.; Payne, R. J. Total Synthesis of Polydiscamides B, C, and D via a Convergent Native Chemical Ligation-Oxidation Strategy. Org. Lett. 2014, 16, 4500-4503.
  167. McDonald, D. M.; Wilkinson, B. L.; Corcillius, L.; Thaysen- Andersen, M.; Byrne, S. N.; Payne, R. J. Synthesis and Immunological Evaluation of Self-Adjuvanting MUC1-Macrophage Activating Lipopeptide 2 Conjugate Vaccine Candidates. Chem. Commun. 2014, 50, 10273-10276.
  168. Liu, X.; Malins, L. R.; Roche, M.; Sterjovski, J.; Duncan, R.; Garcia, M. L.; Barnes, N. C.; Anderson, D. A.; Stone, M. J.; Gorry, P. R.; Payne, R. J. Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library to Interrogate HIV Binding and Entry. ACS Chem. Biol. 2014, 9(9), 2074-2081.
  169. Thompson, R. E. Liu, X.; Alonso-Garcia, N.; Pereira, P. J. B.; Jolliffe, K. A.; Payne, R. J. Trifluoroethanethiol: An Efficient Additive for One-Pot Ligation-Desulfurization Chemistry. J. Am. Chem. Soc. 2014, 136(23), 8161-8164.
  170. Huma, Z.; Ludeman, J. P.; Wilkinson, B. L.; Payne, R. J. Stone, M. J. NMR Characterization of Cooperativity: Fast Ligand Binding Coupled to Slow Protein Dimerization. Chem. Sci. 2014, 5, 2783-2788.
  171. Hsieh, Y. S.; Wilkinson, B. L.; Wijeyewickrema, L. C.; Pike, R. N.; Payne, R. J. Total Synthesis of Homogeneous Variants of Hirudin P6: A Post-Translationally Modified Anti-Thrombotic Leech-Derived Protein. Angew. Chem. Int. Ed. 2014, 53, 3947-3951. (Highlighted in Chemistry in Australia).
  172. Thompson, R. E.; Collin, F.; Maxwell, A.; Jolliffe, K. A.; Payne, R. J. Synthesis of Full Length and Truncated Microcin B17 Analogues as DNA Gyrase Poisons. Org. Biomol. Chem. 2014, 12(10), 1570-1578.
  173. Maghzal, G. J. Cergol, K. M.; Shengule, S. R.; Suarna, C.; Newington, D.; Kettle, A. J.; Payne, R. J.; Stocker, R. Assessment of Myeloperoxidase Activity by the Conversion of Hydroethidine to 2-Chloroethidium. J. Biol. Chem. 2014, 289(9), 5580-5595.
  174. Cergol, K. M.; Thompson, R. E.; Malins, L. R.; Turner, P.; Payne, R. J. One-pot peptide ligation-desulfurization at glutamate. Org Lett. 2014, 16(1), 290-293.
  175. Malins, L. R.; Cergol, K. M. Payne, R. J. Chemoselective Sulfenylation and Peptide Ligation at Tryptophan. Chem. Sci. 2014, 5, 260-266.
  176. Malins, L. R.; Mitchell, N. Payne, R. J. Peptide Ligation Chemistry at Selenol Amino Acids. J. Pept. Sci.2014, 20(2), 64-77. (invited submission for a special issue on chemical protein synthesis).
  177. Corcilius, L.; Payne, R. J. Stereoselective Synthesis of Sialylated Tumor-Associated Glycosylamino Acids. Org. Lett. 2013, 15(22), 5794-5797.
  178. Tran, A. T.; Wen, D.; West, N. P.; Baker, E. N.; Britton, W. J.; Payne, R. J. Inhibition Studies on Mycobacterium tuberculosis N-acetylglucosamine-1-phosphate uridyltransferase (GlmU). Org. Biomol. Chem. 2013, 11, 8113-8126.
  179. Thompson, R. E.; Chan, B.; Radom, L.; Jolliffe, K. A.; Payne, R. J. Chemoselective Ligation-Desulfurization at Aspartate. Angew. Chem. Int. Ed. 2013, 52(37), 9723-9727.
  180. Al Sheikha, D.; Wilkinson, B. L.; Santhakumar, G.; Thaysen-Andersen. M.; Payne, R. J. Synthesis of Homogeneous MUC1 Oligomers via a Bi-Directional Ligation Strategy. Org. Biomol. Chem. 2013, 11, 6090-6096.
  181. Ziarek, J. J.; Getschman, A. E.; Butler, S. J.; Taleski, D.; Stephens, B.; Kufareva, I.; Handel T.M.; Payne, R. J.; Volkman, B. F. Sulfopeptide Probes of the CXCR4/CXCL12 Interface Reveal Oligomer-Specific Contacts and Chemokine Allostery. ACS Chem. Biol. 2013, 8(9), 1955-1963.
  182. Giltrap, A. M.; Cergol, K. M.; Pang, A.; Britton, W. J.; Payne, R. J. Total synthesis of fellutamide B and deoxy-fellutamides B, C, and D. Mar. Drugs. 2013, 11(7), 2382-2397.
  183. Collin, F.; Thompson, R. E.; Jolliffe, K. A.; Payne, R. J.; Maxwell, A. Fragments of the Bacterial Toxin Microcin B17 as Gyrase Poisons. PLoS ONE, 2013, 8(4), e61459.
  184. Roche, M.; Salimi, H.; Duncan, R.; Wilkinson, B. L.; Chikere, K.; Moore, M. S.; Webb, N.; Zappi, N.; Sterjovski, J.; Flynn, J.; Ellett, A.; Gray, L. R.; Lee, B.; Jubb, B.; Westby, M.; Ramsland, P. A.; Lewin, S. R.; Payne, R. J.; Churchill, M. J.; Gorry, P. R. A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology, 2013, 10:43.
  185. Corcilius, L.; Santhakumar, G.; Stone, R. S.; Capiccioti, C. J.; Matthews, J. M.; Ben, R. N.; Payne, R. J. Synthesis of Peptides and Glycopeptides with Polyproline II Helical Topology as Potential Antifreeze Molecules. Bioorg. Med. Chem. 2013, 21(12), 3569-3581. (invited submission for special issue for the 2012 Tetrahedron Prize for Bioorganic and Medicinal Chemistry, Professor Ashraf Brik).
  186. Tan, J. H. Y.; Ludeman, J. P.; Wedderburn, J.; Canals, M.; Hall, P.; Butler, S. J.; Taleski, D.; Christopoulos, A.; Hickey, M. J.; Payne, R. J.; Stone, M. J. Tyrosine Sulfation of Chemokine Receptor CCR2 Enhances Interactions with Both Monomeric and Dimeric Forms of the Chemokine Monocyte Chemoattractant Protein-1 (MCP-1). J. Biol. Chem. 2013, 288(14), 10024-10034.
  187. Malins, L. R.; Cergol, K. M.; Payne, R. J. Peptide Ligation-Desulfurization Chemistry at Arginine. ChemBioChem 2013, 4(5), 559-563.
  188. Payne, R. J. Total Synthesis of Erythropoietin through the Development and Exploitation of Enabling Synthetic Technologies. Angew. Chem. Int. Ed. 2013, 52(2), 505-507.
  189. Bakmiwewa, S. M.; Fatokun, A. A.; Tran, A.; Payne, R. J.; Hunt, N. H.; Ball, H. J. Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2. Bioorg. Med. Chem. Lett. 2012, 22(24), 7641-7646.
  190. Wilkinson, B. L.; Day, S.; Chapman, R.; Perrier, S.; Apostolopoulos, V.; Payne, R. J. Synthesis and Immunological Evaluation of Self-Assembling and Self-Adjuvanting Tricomponent Glycopeptide Cancer-Vaccine Candidates. Chem. Eur. J. 2012, 18(51), 16540-16548.
  191. Manos-Turvey, A; Cergol, K. M.; Salam, N. K.; Bulloch, E. M.; Chi, G.; Pang, A.; Britton, W. J.; West, N. P.; Baker, E. N.; Lott, J. S.; Payne, R. J. Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Org. Biomol. Chem. 2012, 10(46), 9223-9236.
  192. Thompson, R. E.; Payne, R. J.; Jolliffe, K. A. Total Synthesis of Cyclocitropside A and Its Conversion to Cyclocitropsides B and C via Asparagine Deamination. Org. Lett., 2012, 14(19), 5110-5113.
  193. Andrews, D. U.; Heazlewood, B. R.; Maccarone, A. T.; Conroy, T.; Payne, R. J.; Jordan, M. J. Kable, S. H. Photo-tautomerization of Acetaldehyde to Vinyl Alcohol: A Potential Route to Tropospheric Acids. Science. 2012, 337, 1203-1206.
  194. Malins, L. R.; Payne, R. J. Synthesis and Utility of β-Selenol-Phenylalanine for Native Chemical Ligation-Deselenization Chemistry. Org Lett. 2012, 14 (12), 3142-3145.
  195. Chi, G.; Manos-Turvey, A.; O’Connor, P. D.; Johnston, J. M.; Evans, G. L.; Baker, E. N.; Payne, R. J.; Lott, J. S.; Bulloch, E. M. Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis. Biochemistry. 2012, 51 (24), 4868-4879.
  196. Duncan, R. C.; Mohlin, F.; Taleski, D.; Coetzer, T. H.; Huntington, J. A.; Payne, R. J.; Blom, A. M.; Pike, R. N.; Wijeyewickrema, L. C. Identification of a Catalytic Exosite for Complement Component C4 on the Serine Protease Domain of C1s. J. Immunol., 2012, 189(5), 2365-2373.
  197. Hsieh, Y. S.; Wilkinson, B. L.; O’Connell, M. R.; Mackay, J. P.; Matthews, J. M.; Payne R. J. Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Org. Lett., 2012, 14(7), 1910-1913. (Highlighted in the Peptides virtual issue for research published in J. Am. Chem. Soc., Org. Lett. and J. Org. Chem).
  198. Tran, A. T.; West, N. P.; Britton, W. J.; Payne, R. J. Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem, 2012, 7(6), 1031-1043.
  199. Tan, J. H.; Canals, M.; Ludeman, J. P.; Wedderburn, J.; Boston, C.; Butler, S. J.; Carrick, A. M.; Parody, T. R.; Taleski, D.; Christopoulos, A.; Payne, R. J.; Stone, M. J. Design and receptor interactions of an obligate dimeric mutant of the chemokine monocyte chemoattractant protein-1 (MCP-1). J. Biol. Chem., 2012, 287(18), 14692-14702.
  200. Wilkinson, B. L.; Stone, R. S.; Capiccioti, C. J.; Thaysen-Anderson, M.; Matthews, J. M.; Packer, N. H.; Ben, R. N.; Payne, R. J. Total Synthesis of Antifreeze Glycopeptides and Glycoproteins. Angew. Chem. Int. Ed., 2012, 51(15), 3606-3610.
  201. Graham, M. E.; Stone, R. S.; Robinson, P. E.; Payne, R. J. Synthesis and Protein Binding Studies of a Peptide Fragment of Clathrin Assembly Protein 180 AP180 Bearing an O-Linked β-N-Acetylglucosaminyl-6-Phosphate Modification. Org. Biomol. Chem. 2012, 10, 2545-2551.
  202. Hsieh, Y. S.; Taleski, D.; Wilkinson, B. L.; Wijeyewickrema, L. C.; Adams, T. E.; Pike, R. N.; Payne, RJ. Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin. Chem. Commun. 2012, 48, 1547-1549. (Included in the 2012 Emerging Investigators Issue).
  203. Thaysen-Andersen, M.; Wilkinson, B. L.; Payne, R. J.; Packer, N. H. Site-specific characterisation of densely O-glycosylated mucin-type peptides using electron transfer dissociation ESI-MS/MS. Electrophoresis 2011, 32(24), 3536-3545.
  204. Conroy, T.; Guo, J. T.; Linington, R. G.; Hunt, N. H.; Payne RJ. Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A. Chem. Eur. J. 2011, 17(48), 13544-13552.
  205. Thomas, G. L.; Hsieh, Y. S.; Chun, C. K. Y.; Cai, Z. L.; Reimers, J. R.; Payne, R. J. Peptide ligations accelerated by N-terminal aspartate and glutamate residues. Org. Lett. 2011, 13(18), 4770-4773.
  206. Taleski, D.; Butler, S. J.; Stone, M. J.; Payne, R. J. Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides. Chem. Asian J. 2011, 6(6), 1316-1320.
  207. Kakwere, H.; Payne, R. J.; Jolliffe, K. A. Perrier, S. Self-assembling macromolecular chimeras: Controlling fibrillization of a beta-sheet forming peptide by polymer conjugation. Soft Matter, 2011, 7 (8), 3754-3757.
  208. West, N. P.; Cergol, K. M.; Xue, M.; Randall, E. J.; Britton, W. J.; Payne, R. J. Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chem. Commun. 2011, 47(18), 5166-5168. (Included as cover picture.)
  209. Dias, M.V.; Snee, W. C.; Bromfield, K. M.; Payne, R. J.; Palaninathan, S. K.; Ciulli, A.; Howard, N. I.; Abell, C.; Sacchettini, J. C.; Blundell, T. L. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011, 436(3), 729-739.
  210. Wilkinson, B. L.; Day, S.; Malins, L. R.; Apostolopoulos, V.; Payne, R. J. Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer. Angew. Chem. Int. Ed. 2011, 50(7), 1635-1639.
  211. Thompson, R. E.; Jolliffe, K. A.; Payne, R. J. Total Synthesis of Microcin B17 via a Fragment Condensation Approach. Org. Lett. 2011, 13(4), 680-683.
  212. Zhu, J. Z.; Millard, C. J.; Ludeman, J. P.; Simpson, L. S.; Clayton, D. J.; Payne, R. J.; Widlanski, T. S.; Stone, M. J. Tyrosine Sulfation Influences the Chemokine-Binding Selectivity of Peptides Derived from Chemokine Receptor CCR3. Biochemistry 2011, 50(9), 1524-1534.
  213. Tran, A. T.; Cergol, K. M.; West, N. P.; Randall, E. J.; Britton, W. J.; Bokhari, S. A. I; Ibrahim, M.; Lapthorn, A. J; Payne, R. J. Synthesis and Evaluation of Potent Ene-yne Inhibitors of Type II Dehydroquinases as Tuberculosis Drug Leads. ChemMedChem 2011, 6(2), 262-265. (Invited submission for special issue on rare and neglected diseases).
  214. Chim, N.; Habel, J. E.; Johnston, J. M.; Krieger, I.; Miallau, L.; Sankaranarayanan, R.; Morse, R. P.; Bruning, J.; Swanson, S.; Kim, H.; Kim, C. Y.; Li, H.; Bulloch, E. M.; Payne, R. J.; Manos-Turvey A.; Hung, L. W.; Baker, E. N.; Lott, J. S.; James, M. N.; Terwilliger, T. C.; Eisenberg, D. S.; Sacchettini, J. C.; Goulding, C. W. The TB Structural Genomics Consortium: A decade of progress. Tuberculosis 2011, 91(2), 155-172.
  215. Wilkinson, B. L.; Chun, C. K. Y.; Payne, R. J. Synthesis of MUC1 glycopeptide thioesters and ligation via direct aminolysis. Pept. Sci. 2011, 96(2), 137-146. (Special Issue: The Eighth Australian Peptide Conference: Peptides – Tools, Targets and Therapeutics.)
  216. Wilkinson, B. L.; Malins, L. R.; Chun, C. K.; Payne R. J. Synthesis of MUC1-lipopeptide chimeras. Chem Commun. 2010, 46(34), 6249-6251.
  217. Conroy, T.; Guo, J. T.; Hunt, N. H.; Payne, R. J. Total Synthesis and Antimalarial Activity of Symplostatin 4. Org. Lett. 2010, 12(23), 5576-5579.
  218. Tran, A. T.; Cergol, K. M.; Britton, W. J.; Bokhari, S. A. I.; Ibrahim, M.; Lapthorn, A. J.; Payne, R. J. Rapid assembly of potent type II dehydroquinase inhibitors via “Click” chemistry. Med. Chem. Commun. 2010, 1, 271-275.
  219. Holt, D. J.; Payne, R.J.; Chow, W.Y. and Abell, C. Fluorosurfactants for microdroplets: interfacial tension analysis. J. Colloid Interface Sci. 2010, 350, 205-211.
  220. Manos-Turvey A.; Bulloch, E. M. M.; Rutledge, P. J.; Baker, E. N.; Lott, J. S.; Payne, R. J. Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem 2010, 5, 1067-1079. (Included as cover picture).
  221. Conroy, T.; Jolliffe, K. A.; Payne, R. J. Synthesis of N-linked glycopeptides via solid-phase aspartylation. Org. Biomol. Chem. 2010, 8, 3723-3733.
  222. Payne, R.J.; Bulloch, E. M. M.; Kerbarh, O.; Abell, C. Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Org. Biomol. Chem. 2010, 8, 3534-3542.
  223. Kakwere, H.; Chun C. K. Y.; Jolliffe, K. A.; Payne, R. J.; Perrier S. Polymer-peptide chimeras for the multivalent display of immunogenic peptides. Chem. Commun. 2010, 46, 2188-2190. (Included as cover picture).
  224. Holt, D. J.; Payne, R. J.; Abell, C. Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams. J. Fluor. Chem. 2010, 131, 398-407.
  225. Payne, R. J.; Wong, C-H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chem. Commun. 2010, 46, 21-43.
  226. Garner, J.; Jolliffe, K. A.; Harding, M. M.; Payne, R. J. Synthesis of homogeneous antifreeze glycopeptides via a ligation-desulfurisation strategy. Chem. Commun. 2009, 6925-6927.
  227. Thomas, G. L.; Payne, R. J. Phosphate-assisted ligation. Chem. Commun. 2009, 4260-4262. (Highlighted in meet our authors section).
  228. Chun, C. K. Y.; Payne, R. J. Synthesis of MUC1 peptide and glycopeptide dendrimers. Aust. J. Chem. 2009, 1339-1343 (Invited submission for feature edition on Bioconjugate Chemistry).
  229. Conroy, T.; Jolliffe, K. A.; Payne, R. J. Efficient use of the Dmab protecting group: applications for the solid-phase synthesis of N-linked glycopeptides. Org. Biomol. Chem. 2009, 7, 2255-2258.
  230. Payne, R. J.; Bulloch, E. M. M.; Toscano, M. M.; Jones, M. A.; Kerbarh, O.; Abell, C. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes. Org. Biomol. Chem. 2009, 7, 2421-2429.
  231. Bennett, C. S.; Dean S. M.; Payne R.J.; Ficht S.; Brik A.; Wong C.-H. Sugar-Assisted Glycopeptide Ligation with Complex Oligosaccharides: Scope and Limitations. J. Am. Chem. Soc. 2008, 130, 11945-11952.
  232. Payne, R. J.; Ficht, S.; Greenberg, W. A.; Wong, C.-H. Cysteine-Free Peptide and Glycopeptide Ligation by Direct Aminolysis. Angew. Chem. Int. Ed. Engl. 2008, 47, 4411-4415.
  233. Ficht, S.; Payne, R. J.; Guy, R. T.; Wong, C.-H. Solid-Phase Synthesis of Peptide and Glycopeptide Thioesters through Side-Chain-Anchoring Strategies. Chem. Eur. J. 2008, 14, 3620-3629.
  234. Payne, R. J.; Ficht, S.; Tang, S.; Brik, A.; Yang, Y-Y.; Case D.; Wong C.-H. Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope and Applications. J. Am. Chem. Soc. 2007, 44, 13527-13536.
  235. Ficht, S.; Payne, R. J.; Brik, A.; Wong, C.-H. Second-Generation Sugar-Assisted Ligation: A Method for the Synthesis of Cysteine-Containing Glycopeptides. Angew. Chem. Int. Ed. Engl. 2007, 46, 5975-5979.
  236. Payne, R. J.; Peyrot, F.; Kerbarh, O.; Abell, A. D.; Abell, C. Rational Design, Synthesis, and Evaluation of Nanomolar Type II Dehydroquinase Inhibitors. ChemMedChem 2007, 2(7), 1015-1029.
  237. Payne, R. J.; Riboldi-Tunnicliffe, A.; Kerbarh, O.; Abell, A. D.; Lapthorn, A. J.; Abell, C. Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases. ChemMedChem 2007, 2(7), 1010-1013.
  238. Abell, A. D.; Jones, M. A.; Neffe, A. T.; Aitken, S. G.; Cain, T. P.; Payne, R. J.; McNabb, S. B.; Coxon, J. M.; Stuart, B. G.; Pearson, D.; Lee, H. Y.-Y.; Morton, J. D. Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents. J. Med. Chem. 2007, 50(12), 2916-2920.
  239. Toscano, M. D.; Payne, R. J.; Chiba, A.; Kerbarh, O.; Abell, C. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism. ChemMedChem 2007, 2(1), 101-112.
  240. Payne, R. J.; Bulloch, E. M. M.; Abell, A. D.; Abell, C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Org. Biomol. Chem. 2005, 3(20), 3629-3635.
  241. Payne, R. J.; Toscano, M. D.; Bulloch, E. M. M.; Abell, A. D.; Abell, C. Design and synthesis of aromatic inhibitors of anthranilate synthase. Org. Biomol. Chem. 2005, 3(12), 2271-2281. (Included as a cover picture)
  242. Payne, R. J.; Kerbarh, O.; Miguel, R. N.; Abell, A. D.; Abell, C. Inhibition studies on salicylate synthase. Org. Biomol. Chem. 2005, 3(10), 1825-1827.
  243. Payne, R.; Edmonds, M. Isolation of shikimic acid from star aniseed. J. Chem. Ed. 2005, 82(4), 599-600. (Included as a cover picture)
  244. Kerbarh, O.; Bulloch, E. M. M.; Payne, R. J.; Sahr, T.; Rebeille, F.; Abell, C.; Mechanistic and Inhibition Studies of Chorismate-Utilising Enzymes. Biochem. Soc. Trans. 2005, 33(4), 763-766.
  245. Payne, R. J.; Daines, A. M.; Clark, B. M.; Abell, A. D. Synthesis and protein conjugation studies of vitamin K analogues. Bioorg. Med. Chem. 2004, 12(22), 5785-5791.
  246. Payne, R. J.; Brown, K. M.; Coxon, J. M.; Morton, J. D.; Lee, H. Y.-Y.; Abell, A. D. Peptidic Aldehydes Based on α – and β -Amino Acids: Synthesis, Inhibition of m-Calpain, and Anti-Cataract Properties. Aust. J. Chem. 2004, 57(9), 877-884.
  247. Daines, A. M.; Payne, R. J.; Humphries, M. E.; Abell, A. D. The synthesis of naturally occurring vitamin K and vitamin K analogues. Curr. Org. Chem. 2003, 7(16), 1625-1634.
  248. de Zwart, F. J.; Slow, S.; Payne, R. J.; Lever, M.; George, P. M.; Gerrard, J. A.; Chambers, S. T. Glycine Betaine and Glycine Betaine Analogues in Common Foods. Food Chem. 2003, 83(2), 197-204.

BOOK CHAPTERS, HIGHLIGHTS & FORWARDS

  1. Kambanis, L.; Kulkarni,S. S.; Payne, R. J. Side-Chain Anchoring Strategies for the Synthesis of Peptide Thioesters and Selenoesters. In Methods Mol. Biol. 2022, 2530, 125-140.
  2. Bedding, M. J.;  Kulkarni, S. S.; Payne, R. J. Chapter Fifteen – Diselenide-selenoester ligation in the chemical synthesis of proteins. Methods in Enzymology, Ed. Academic Press: 2022; Vol. 662, pp 363-399.
  3. Ashhurst A.S., Hanna C.C., Payne R.J., Britton W.J. (2022) Immunological Assessment of Lung Responses to Inhalational Lipoprotein Vaccines Against Bacterial Pathogens. In: Bidmos F., Bossé J., Langford P. (eds) Bacterial Vaccines. Methods in Molecular Biology, vol 2414. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1900-1_16
  4. Malins, L. R.; Payne, R. J. Chemoselective Ligation Methods Based on the Concept of Native Chemical Ligation. In Science of Synthesis (Thieme) 2022, chapter 21.11.7
  5. Watson, E. E.; Malins, L. R.; Payne, R. J. Chapter 5 – Expanding Native Chemical Ligation Methodology with Synthetic Amino Acid Derivatives. Chemical Synthesis of Proteins (Wiley) 2021, Chapter 5, pg 119-129, DOI: 10.1002/9783527823567
  6. Payne, R. J.; Winssinger, N. Editorial Overview: Synthetic biomolecules. Current Opinion in Chemical Biology 2018, 46, A3-A4.
  7. Payne, R. J. Preface: Bioactive Molecules Australiasia. Tetrahedron 2018, 74(12), 1165-1166.
  8. Premdjee, B.; Payne, R. J. Synthesis of Proteins by Native Chemical Ligation–Desulfurization Strategies. In Chemical Ligation: Tools for Biomolecule Synthesis and Modification (Wiley), 2017, 161-222.
  9. Watson, E. E.; Payne, R. J. 4-Nitrophenylchloroformate. Encyclopedia for Reagents in Organic Synthesis 2017.
  10. Malins, L. R.; Payne, R. J. Modern Extensions of Native Chemical Ligation for Chemical Protein Synthesis. Top. Curr. Chem. (Springer), 2015, 362, 27-87.
  11. Payne, R. J. Carbohydrates: The Essential Molecules of Life. Aust. J. Chem. 2009, 62, 1-2.
  12. Bennett, C. S.; Payne, R. J.; Koeller, K. M.; Wong, C.-H. Synthesis and applications of biologically relevant glycopeptides. Glycoscience (Vol III), 2008, Fraser-Reid, B.O.; Tatsuta, K.; Thiem, J.; Coté, G.L.; Flitsch, S.; Ito, Y.; Kondo, H.; Nishimura, S.; Yu, B. (Eds.) Springer Berlin Heidelberg, 1795-1857.

PATENTS

  1. Chisholm, T; Payne R. J. “Flow Peptide and Protein Synthesis” Australian Provisional Patent filed 06/06/2018.
  2. Tran, A. T.; Tran, W.; Britton, W. J.; Payne, R. J. “Novel TB Drugs” Australian Provisional Patent filed 17/12/2016.
  3. Pereira, P. J. B.; Jackson, S. J.; Payne, R. J. “Antithrombotic Peptides” Australian Provisional Patent filed 17/12/2016.
  4. Mitchell, N. J.; Malins, L. R.; Payne, R. J. “Protein Synthesis” Australian Provisional Patent filed 26/02/2015.
  5. Thompson, R. E.; Payne, R. J. “Peptide Ligation” Australian Provisional Patent filed 22/05/2014.
  6. Wilkinson, B. L.; Day, S.; Apostolopoulos, V; Payne, R. J. “Glycopeptide Cancer Vaccine Candidates” APPA Number: 2010905492, December 15, 2010.
  7. West, N.; Payne, R. J.: Britton, W. J. “Inhibitors of Rv3802c as Tuberculosis Drug Leads” APPA Number: 2011900133, January 14, 2011.
  8. Thomas, G. L.; Payne R. J. “Peptide Synthesis” 20090331 – 61631AUV00 – Filed Provisional Application.
  9. Brik, A.; Yang, Y.-Y.; Ficht, S; Payne, R. J.; Wong, C.-H. “Method of Preparing Glycopeptides” Application Serial Number-60/743,666, U.S. Patent Application filed March 22, 2007.